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COVID-19 Antibody Detection On-Site With High Sensitivity

Various vaccinations for SARS-CoV-2 have indeed been discovered, and vaccinations are being carried out all over the globe.

Antibodies testing, which uses a technology termed immune-chromatography, are used in the healthcare industry to evaluate if antigens were created as a consequence of viral acute infection.

COVID-19 Antibody Detection On-Site With High Sensitivity

The infection among people must be checked at the earliest to curb the spread of this virus. The methods that are used for such testing matter a lot and in most cases before the results declare the patient may have roamed to many places spreading the infection.

This new and quick method will help one know the results in a few minutes so that one can be sure about a further course of action.

The findings of this test, though, are not accurate or accurate since they are obtained by gazing at colored stripes on parchment with the human eye. To make matters worse, blood tests should be submitted to an outside test center for more exact, results, which can take anywhere from a few days maybe a week.

A scientific community at the RIKEN Centre for Emergent Matter Science (CEMS) has devised a qualified medical that could determine the number of autoantibodies that may defend us all from SARS-CoV-2, the viruses that produce COVID-19, quickly and accurately. This breakthrough was reported in the scholarly journal Proceedings of the Chemical Society and it is intended to make SARS-CoV-2 vaccination effectiveness testing more fast and accurate at healthcare facilities.

The method relies on the utilization of sunlight. After coating a plastic microchip with a light-reactive material, a test fluid carrying the specific protein is deposited onto the microprocessor in the shape of a patch. The microchip is then subjected to UV radiation, which causes the antibodies to become immobilized.

The scientists used this technology to create a microarray chip on which critical SARS-CoV-2 genes are fixed. When antigens in serum samples attach to virion on the chip, illumination is produced, and the quantity of light radiated can be accurately quantified using a CCD camera. As a result, this value can be used to measure the number of antibodies in a manner that immunochromatography cannot.

The latest study is lead by Yoshihiro Ito of RIKEN CEMS, who created a method that immobilizes any organic component, particularly biological compounds, several decades previously. Ito and his team have worked to develop the method since then, concentrating on immobilizing diverse allergens in order to track the course of immunological illness.

They already have managed to establish a test kit based on a chip that is immobilized with over 40 distinct allergies. They’ve now expanded their diagnostic capabilities to include a technique that immobilizes numerous important SARS-CoV-2 proteins, enabling the automated detection of antibodies to SARS-CoV-2.

“Standard quantitative analysis of antibodies usually requires a half milliliter of blood drawn from one of your arms, which is a lot!” says Ito. “But in our system, all that is needed is a small drop of blood from the fingertip, and the sensitivity of the system is 500 times higher than that of conventional immunochromatography, meaning that detection is possible even when the number of antibodies is very low.”

“In the past, our team has succeeded in developing antibody detection systems for measles, rubella, and chickenpox. Now we can also detect antibodies for the COVID-19 virus. This system is practical to use and will enable precision testing at any medical facility, making it easier to quickly determine on-site whether or not vaccination is necessary. It can also be used to conduct epidemiological surveys in preparation for future pandemics,” says Ito.

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