COVID report says that many people face different COVID symptom situations and causes. Usually, older people will face underlying problems that show effects on diseases such as diabetes, cancer, chronic respiratory diseases, cardiovascular diseases, and other diseases that cause severe illness.
Why Some COVID Cases Are Deadly Among People, While Some Not
People of all ages will be affected by COVID-19 except younger kids because their immune system is strong enough compared to older people. Older people have huge chances of getting affected by a coronavirus.
Researchers say that if people are pre-existed with severe health conditions such as diabetes, heart diseases, and asthma, they will develop the most vulnerable and severe illness when they get transmitted to COVID-19.
Investigators state that people who are in a severe death condition due to transmission of COVID-19, those people must have an underlying cause of different diseases like obesity, diabetes, kidney disease, etc. Still, in some cases, there are many explanations that obesity and diabetes are already associated with the weaker immune system, which is always resistant to infections.
The study says that a severe underlying cause in general circumstances will make the person’s medical condition a lesser ability among the vital organs and affect biological stresses through inflammation and infection.
Many researchers have suggested that most treatments have common causes like diabetes and higher blood pressure, leading to the severe risk of COVID-19. Some drugs can help boost the ACE2 levels in the body, which are situated on the cell-surface enzyme, which uses the COVID-19 infection to get inside the cells.
Researchers conduct many clinical studies to know the drug abilities of the COVID people with severe conditions. According to a recent medical survey, people are mostly affected with 80 to 90 percent. Among those cases, 10 to 20 percent of people are reported with mild cases and are experiencing life-threatening symptoms.
Medical research decided to research mice possessed with human-like immune systems in the laboratory. These mice are named “humanized mice,” This clinical analysis revealed some proof that severe COVID might be treated with antiviral inflammatory responses towards the coronavirus.
More studies are being conducted because many variant strains are developing. Right now, the Omicron strain has been transmitting around the world.
This study says that two available therapies can help treat antiviral virus transmission. Those therapies are steroid dexamethasone and monoclonal antibodies, and these are results for the treatment of severe COVID infections.
In most cases, this antiviral medication is only applicable for the people who start the course at an early stage after the transmission of the virus because all the immune systems do not respond the same while they develop with different symptoms, say scientists.
Authors of this study say that “if the mice are tested with another variant SARS-CoV-2 then it will infect but doesn’t get ill, in the same way, if we inject the virus into invented humanized mice then it will get sever sick and will not get better” this happens in humanized mice only because its whole immune system is already heavy.
EsenSefik is the lead researcher of this study; he and his research team have introduced the second variant of the virus and injected the strain into humanized mice to educate the people about the course of this variant.
After several investigations and clinical research, the study noted that the viral infection is fatal among mice in the initial stages and showed initial suppression of immune response, which is a crucial step for combating the virus. This clue has helped in clearing the inflammatory reactions of infection. The study believes that humanized mice may reveal more strong clues if the research continues on the potential treatments with a strong research basis.
