Probiotic-Rich Yoghurt Prevents Antibiotic-Induced Diarrhea

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The researchers discovered that yogurt, including the probiotics Bifidobacterium Lactobacillus BB-12, maintained the colon’s bacterial population longer as a placebo. The results seemed so promising that the National Institutes of Health decided to finance second research.

Diarrhea is an ailment caused by a bacterial infection in the colon, which leads to severe weakness if one has to face it for a more extended period.

Probiotic-Rich Yoghurt Prevents Antibiotic-Induced Diarrhea

Yogurt is considered as a realistic option that can counter such bacteria and remove the infection leading one free from the disease. The consumption of the same can also help one keep away from weakness, and in a couple of days, the health can be back on track.

Consuming yogurt with a specific type of very healthy probiotics seems to guard it prevent adverse alterations in the intestinal microbiota which come from antibiotics use. It concludes a novel randomized trial led by scientists and reported in the magazine Phytonutrients lately.

Probiotic-Rich Yoghurt Prevents Antibiotic-Induced Diarrhea

“This finding provides important new insights into the mechanisms by which the probiotic, BB-12, may protect against antibiotic-associated diarrhea,” said study co-leader Claire Fraser, Ph.D., Professor of Medicine and Dean’s Endowed Professor of UMSOM and Director of the UMSOM Institute for Genome Sciences.

“The new insights that we obtained regarding BB-12 reflect the multi-omics approach we used in our study. It was possible only because of the different expertise that each principal investigator brought to this collaboration.”

Antibacterial drugs diarrhea affects approximately one in every five persons who use antibiotics because the medications damage the normal gut microbiota.

Individuals might cease using their prescriptions too soon after experiencing diarrhea, leading to the illness returning. C. difficile, which can live in the stomach but is normally held in control by beneficial microorganisms in the microbiota, could cause an existing illness in a tiny number of people.

Forty-two normal participants are arbitrarily randomized to ingest a regular serving-size bottle of BB-12-fortified yogurt, including an ordinary week-long antimicrobial course of amoxicillin-clavulanic acid in the research. Following completing the medication, they continue to eat yogurt each day for a week.

A total of 20 people were allocated to the comparison group, who were given a regular yogurt even without probiotics for two weeks while simultaneously receiving the same antibiotics treatment.

The scientists intend to do follow-up research to delve deeper into this subject and determine the optimal timing to take a probiotic.

“The School of Pharmacy’s Mass Spectrometry Center lends its expertise to a wide array of research studies and projects, demonstrating the enormous value of this technology,” said Natalie D. Eddington, Ph.D., FAAPS, FCP, Professor.

“Working with 17 mass spectrometers, our faculty, staff, and graduate students contribute to discoveries that span basic biology and medicine to technology development and translational research.”

“An important reason why our study may have demonstrated positive results may be the timing of the probiotic administration on the day antibiotics were initiated by the study volunteers,” said study co-leader Daniel Merenstein, MD, Professor of Family Medicine and Director of Research Programs.

“Starting the probiotic as early as possible, before the antibiotic symptoms have progressed, may result in a greater opportunity for the probiotic mechanisms to be expressed and may ultimately lead to more beneficial clinical outcomes.”

“Our researchers seek to advance treatments for patients by truly understanding the mechanisms behind those treatments using sophisticated technologies. We are delighted to be able to collaborate with the School of Pharmacy and its distinguished faculty on this very important project,” said E. Albert Reece.

“The multi-disciplinary approach to understanding how probiotics work to maintain a healthy microbiome is crucial for advancing this field and ultimately helping patients avoid debilitating side effects from antibiotics.”


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