Top 5 Best Cortisol Blocker Supplements on the Market to Reduce Stress Naturally

Stress is the worst add-on in the life of modern men and women. Whether you are a student or an entrepreneur, stress can plague your life indefinitely and hamper your thinking capabilities beyond repair. Therefore, addressing stress and your overall mental health is essential if you want to shine through different aspects of your life.

Our team has selected the best supplements to reduce cortisol (stress hormone) levels in your body.

Which Are The Best Supplements To Reduce Cortisol?

When bringing any changes to your cognitive health, it is best to rely on natural ingredients as they won’t pose any risk to your health. Some supplements are better than others for promoting your brain health.

We looked for natural supplements to reduce cortisol in your body. Here are the best five among them:

  • Xanapril
  • Nooceptin
  • Vyvamind
  • CortiSync
  • NooCube



  • What’s Unique About It: Xanapril boosts confidence, mood, and happiness with the help of clinically-tested ingredients.

Xanapril is an over-the-counter stress supplement designed using clinically safe ingredients. It is an entirely natural anxiety formula based on the latest research by a group of esteemed scientists. Xanapril aims to reduce your stress quickly without inducing any side effects.

Xanapril combines the best of both worlds, science, and nature, to create the most effective results. It helps you fight off stress and anxiety triggers that can ruin your mental health and set you back in your work or studies.

You will find amino acids, minerals, and herbal roots in the formula of Xanapril. You can buy Xanapril without a doctor’s prescription as it contains no harmful compounds.

Xanapril is manufactured in an FDA-inspected facility in the USA with high-quality natural compounds.

Xanapril Benefits

Xanapril is a natural stress and anxiety formula that helps you overcome daily challenges with a calm mind. This supplement reduces the effects of stress on your mind and helps enhance your mental energy and brain power.

It can improve your focus and mental drive to think critically under challenging situations and make the right decisions. Xanapril can protect your brain and allow you to relax after a long day. It quickens the onset of sleep so that your body can repair and recover, and you wake up fresh the next day.

Whether you have back-to-back meetings or presentations or are swamped with deadlines, taking three capsules of Xanapril can rejuvenate your mind and relieve mental fatigue.

More: Xanapril Reviews



  • What’s Unique About It: Nooceptin helps you control your mental abilities by reducing the effects of stress and anxiety.

Nooceptin is a 100% science-backed formula containing a potent blend of neurochemicals and herbal extracts to boost cognitive function. This supplement is made in the USA in an FDA-inspected facility under strict supervision.

This cognitive enhancer can help you get more done in less time so that you have time for your hobbies, exercise, and lifestyle management. Suppose you cannot work without taking constant social media breaks or are constantly distracted even by the slightest sounds. In that case, you must try Noocpetin to enhance your focus and working memory.

All the ingredients found in the formula of Nooceptin are clinically backed to provide long-term cognitive health benefits to users. This supplement is free from artificial stimulants or harmful components that can alter your normal rhythm.

Nooceptin can enhance brain function by entrepreneurs, students, gamers, senior citizens, and athletes.

Nooceptin Benefits

Nooceptin has been endorsed by a neuroscientist for its solid ingredient content and ability to produce effective results. This dietary supplement helps you focus on complex tasks and solve them more accurately. It can clear your mind and eliminate brain fog so that your productivity remains intact even at the end of the day.

This supplement provides a natural energy boost at the cellular level to help you remain active all day. It improves memory retention and recall by promoting neuron growth and protecting brain cells. Nooceptin delivers essential nutrients to your brain cells and helps suppress the production of cortisol, the stress hormone.

More: Nooceptin Reviews



  • What’s Unique About It: Vyvamind increases brain energy by a significant percentage (14%), removes mental fatigue, and enhances productivity.

Vyvamind is a dietary supplement that can be used as a focus aid by individuals who want to unlock maximum brain power during work or study hours. It is a natural formula that only helps you achieve peak mental performance within a few hours. The ingredients in the Vyvamind formula have been clinically tested to improve memory and reduce stress.

The Vyvamind dietary supplement is produced in FDA-inspected facilities in the USA to ensure maximum purity, quality, and potency for users. This neurostimulator has many applications for cognitive health with minimal side effects to support your well-being.

Vyvamind is perfect for high-performers who want to give their best in every situation but are often restricted by brain fatigue and low stamina. This dietary supplement may benefit students, gamers, traders, athletes, business professionals, and individuals with low focus power.

Vyvamind Benefits

The formula of Vyvamind has been designed by professionals exclusively for people who get stuck in mentally demanding situations and are stressed. This supplement can reduce cortisol production and allow you to remain calm and relaxed.

It increases your motivation and makes mental fatigue a thing of the past. Vyvamind can also improve your reaction time so that you can complete tasks with more efficiency. It facilitates cell membrane formulation, which helps improve your overall cognitive function.

Vyvamind nootropic supplement is the right choice if you need help solving problems.

More: VyvaMind Reviews



  • What’s Unique About It: The formula of CortiSync is non-GMO, organic, gluten-free, vegetarian, and scientifically studied to produce the best results.

CortiSync is a doctor-recommended formula that helps in reducing cortisol levels naturally. This supplement comprises clinically-tested ingredients to counter the effects of the ‘stress hormone.’ If you don’t control the growth of cortisol levels, you might remain constantly tired and weak. Cortisol can also lead to weight gain and increased appetite and cravings.

You can take CortiSync without making any significant lifestyle changes. This supplement delivers scientifically researched adaptogens (mainly herbal extracts) to your body that help increase your body’s stress resistance.

The formula of CortiSync has been designed to provide results within two weeks to daily users. It can be obtained without a prescription and does not cause any side effects.

CortiSync Benefits

CortiSync helps improve your mental and physical health by combating the severe effects of the stress hormone. It optimizes cortisol production, creating havoc in your body.

The daily intake of CortiSync can boost your attention span and memory recall, which can help you participate in challenging activities without difficulty. It can enhance focus and reduce distractions to complete your work on time.

The formula of CortiSync contains relaxing compounds that improve sleep, an essential factor behind the overproduction of cortisol.



  • What’s Unique About It: The formula of NooCube contains essential brain nutrients that help promote memory retention and brain-eye coordination.

NooCube is a nootropic supplement that is made in an FDA-inspected facility in the USA. It is free from artificial stimulants and allergens that can cause side effects in your body. This dietary supplement includes free brain guides and newsletter access to enhance mental health knowledge and boost cognitive function.

The formula of NooCube contains science-backed ingredients to provide advanced brain support to daily users. These ingredients work in synergy to maximize your brain health and improve your body’s natural stress response.

NooCube Benefits

NooCube is an all-one-in nootropic formula that is excellent for your cognitive health. This dietary supplement improves your mental health by suppressing the production of cortisol and boosting energy. It increases your stamina to work longer and with enhanced focus.

This supplement increases your brain’s processing speed so you can react quickly to provoking situations and act on them instantly. NooCube nourishes the brain cells and protects them against free radicals to support healthy brain functions.

NooCube helps you with stress management so that you can focus your energy on the right tasks without draining your brain.

More: Noocube Reviews

Does Science Back The Ingredients In The Supplements Listed Above?

Before you purchase any supplement, it’s essential to research and ensure the ingredients are backed by science. After all, you’re investing your time and money into something to improve your health and fitness.

In this section, we’ll take a closer look at the scientific evidence behind the ingredients in the best cortisol-reducing supplements:


One of the core mechanisms by which citicoline helps to reduce cortisol levels is by increasing the production of phosphatidylcholine, a key component of cell membranes. Studies have shown that increased levels of phosphatidylcholine are associated with reduced cortisol levels and increased feelings of calmness and relaxation.

In a specific study, researchers investigated the effects of citicoline on cortisol levels in healthy adults. Participants were given either a placebo or citicoline supplement for 28 days, and cortisol levels were measured before and after the supplementation period.

The results showed that participants who received citicoline had significantly lower cortisol levels than those who received the placebo. Additionally, the citicoline group reported feeling calmer and more relaxed than the placebo group.

Rhodiola Rosea

Rosavin is one of the primary active components in Rhodiola rosea. It is believed responsible for the herb’s antidepressant and anxiolytic effects. Rosavin works by increasing neurotransmitters in the brain, including serotonin and dopamine. These neurotransmitters are responsible for regulating mood and reducing anxiety. Boosting their levels helps Rosavin reduce stress and promote a sense of calmness.

Salidroside is another important active component in Rhodiola rosea. It is believed to have anti-fatigue and anti-stress effects. Salidroside works by increasing the levels of ATP (adenosine triphosphate) in the body. ATP is the primary source of energy for the body’s cells. By increasing its levels, salidroside helps to reduce fatigue and improve physical performance.

Mucuna Pruriens

Mucuna Pruriens, or velvet bean, is a tropical legume used in traditional medicine for centuries. A primary benefit is its ability to reduce cortisol levels.

This is mainly due to the various active components found within the plant. In this article, we will explain in detail the core mechanisms of these components and how they work to reduce stress levels.

L-Dopa is one of the primary active components found in Mucuna Pruriens. It is a precursor to dopamine, which regulates mood and emotions. Dopamine plays a vital role in the body’s stress response system, as it helps regulate cortisol release.


One of the core mechanisms by which GABA helps boost calmness and reduce cortisol levels is by decreasing the hypothalamic-pituitary-adrenal (HPA) axis activity. The HPA axis is a complex system that regulates the body’s response to stress and releases cortisol, the primary stress hormone.

When the body is under stress, cortisol levels increase, leading to a range of physiological responses, including increased heart rate, blood pressure, and respiration. However, when GABA levels are high, it can help to reduce the activity of the HPA axis, resulting in a decrease in cortisol levels and a reduction in stress-related symptoms.


One study that supports using L-Tyrosine for reducing stress and anxiety involved a group of healthy adults exposed to a stressful situation designed to induce a stress response in the body. The participants were then given either a placebo or an L-Tyrosine supplement, and their stress levels were measured using a variety of physiological and psychological tests.

The study results showed that the participants who received the L-Tyrosine supplement had lower cortisol levels and reported feeling less stressed and anxious than those who received the placebo. The researchers concluded that L-Tyrosine may be a helpful supplement for reducing stress and anxiety in healthy adults.

How Did We Choose The Best Supplements To Reduce Cortisol?

Our team considered several ranking factors to determine the best supplements to reduce cortisol levels.

Natural Ingredients

Every nootropic on our list is made from natural ingredients to enhance your cognitive function without causing any side effects. These ingredients include amino acids, minerals, vitamins, and herbal extracts proven scientifically to support healthy brain functions.


We analyzed the results one could receive with these nootropic supplements and ranked them on their effectiveness. Most supplements on our list produce results within 30 days by enhancing your mental performance and supporting improved productivity.

Purity Standards

Every supplement on our list is made in an FDA-inspected facility in the USA under strict and sterile standards. They are free from artificial stimulants, GMOs, dairy, gluten, and other harmful compounds that might harm your body.

Brand Reputation & Advertised Benefits

We looked at the advertised benefits of cortisol-reducing supplements and the studies on which these formulations were based. Also, we included supplements by only those brands with an impeccable reputation in the market for their manufacturing practices.

Pricing & Value

Every supplement on our list is affordable, so the masses can buy them without burning a hole in their pockets. They provide high value to users by improving their brain function and overall health. Most supplements cost $69-79 for one month’s supply. You can also get discounts on buying them in bulk.

Money-Back Guarantee

Another factor that we base our rankings on is the money-back guarantee provided by nootropic supplements. All the supplements on our list come with a 100% money-back guarantee so that users don’t worry about buying them in the first place.

Final Verdict on The Best Supplements To Reduce Cortisol

In today’s age, it is impossible to evade stress. The best you can do is make an effort to manage it so that it does not interfere with your mental and physical health. Taking natural nootropics can help reduce stress levels in your body and improve brain functions like memory, focus, attention, and eyesight.

You can take any cortisol supplement above to enhance your productivity and live a relaxed life.

Related: Adderall Shortage Alternatives (2023)

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Please understand that any advice or guidelines revealed here are not even remotely substitutes for sound medical or financial advice from a licensed healthcare provider or certified financial advisor. Make sure to consult with a professional physician or financial consultant before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary and are not guaranteed as the statements regarding these products have not been evaluated by the Food and Drug Administration or Health Canada. The efficacy of these products has not been confirmed by FDA, or Health Canada approved research. These products are not intended to diagnose, treat, cure or prevent any disease and do not provide any kind of get-rich money scheme. Reviewer is not responsible for pricing inaccuracies. Check product sales page for final prices.

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